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Treating the rats with the female sex hormone estradiol increased urine output and decreased the amount of aqp2. According to the researchers,. The hormone estrogen is responsible for maintaining and driving weight loss in our bodies; however, having an excessive amount of estrogen,. The hormones progesterone and estrogen play a significant role in fluid retention. When estrogen levels are elevated, women tend to retain. Does estrogen cause fluid retention? it does estrogen does cause fluid retention in the body. In this video we look at how estrogen other. Menopause can likewise cause water retention. The loss of estrogen during menopause is associated with increased salt-sensitivity and reduced gfr. Although there were small increases in overall fluid retention during estradiol administration, renal free water clearance was unaffected by estrogen. Estrogen and progesterone can affect your fluid balance and lead to increased water weight. 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